Expressive

rs11012077 (AMD1P1/MIR4675): Height Variant

Key takeaways

  • rs11012077 is one of 12,111 common variants significantly linked to adult height in a genome-wide study of 5.4 million people.
  • These height-linked variants collectively explain about 40% of height variation in people of European ancestry.
  • The same variants explain only 10-20% of height variation in non-European populations, likely due to differences in nearby genetic patterns rather than different biology.
  • No individual effect size for rs11012077 alone is reported; it contributes as part of a larger set of height variants.

Key takeaways

  • rs11012077 is one of 12,111 common genetic variants (SNPs, or single-nucleotide polymorphisms - single-letter changes in the DNA sequence) significantly linked to adult height in a genome-wide study of 5.4 million people.
  • Together, these height-linked variants explain about 40% of height variation in people of European ancestry (or about 45% when all common variants in the HapMap 3 reference panel are included).
  • The same variants explain less height variation in non-European populations (roughly 10-20%), likely due to differences in linkage disequilibrium (the correlation patterns between nearby genetic variants) rather than different underlying biology.
  • No individual effect size for rs11012077 alone is available; its contribution is measured as part of the broader set of height variants.

What the research says rs11012077 is located near AMD1P1 (adenosylmethionine decarboxylase 1 pseudogene 1 - a DNA sequence resembling a gene that does not produce a functional protein) and MIR4675 (microRNA 4675 - a small RNA molecule that can regulate the expression of other genes), and is one of 12,111 independent common variants identified as significantly associated with adult height in a genome-wide meta-analysis of 5.4 million individuals from 281 studies PMID 36224396. These variants are distributed across 7,209 non-overlapping genomic segments averaging around 90 kb in size and covering approximately 21% of the human genome, together accounting for nearly all of the heritability of height attributable to common genetic variants PMID 36224396.

Reported associations

  • Adult height: rs11012077 is one of 12,111 independent common SNPs reaching genome-wide significance in a multi-ancestry genome-wide study of 5.4 million individuals; together these variants explain approximately 40% of phenotypic variance in European-ancestry populations and approximately 10-20% in non-European populations PMID 36224396.

Evidence quality The evidence comes from a very large multi-ancestry meta-analysis of 5.4 million individuals across 281 studies, comprising participants of predominantly European (75.8%), East Asian (8.8%), Hispanic or admixed (8.5%), African (5.5%), and South Asian (1.4%) ancestries PMID 36224396. All 12,111 associated SNPs reached genome-wide significance. Effect sizes and associated regions are reported to be broadly similar across ancestries; the lower predictive accuracy in non-European populations is attributed to differences in linkage disequilibrium patterns and allele frequencies within associated regions rather than to different underlying biology PMID 36224396. No individual effect size for rs11012077 alone is provided in the available study text. The authors note that while the common-variant map is considered saturated for European-ancestry populations, further research is needed to achieve equivalent coverage in other ancestries PMID 36224396. No conflicting findings are reported for this locus.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11012077?

rs11012077 is a common genetic variant located near AMD1P1, a pseudogene (a DNA sequence resembling a gene that does not produce a functional protein), and MIR4675, a microRNA. It was identified in a large genome-wide study as one of thousands of variants significantly linked to adult height.

What genes are near rs11012077?

rs11012077 sits near AMD1P1 (adenosylmethionine decarboxylase 1 pseudogene 1) and MIR4675 (microRNA 4675). AMD1P1 is a pseudogene and MIR4675 is a small RNA molecule. The study identifying this variant focused on its association with height rather than the specific biological roles of nearby genes.

Is rs11012077 associated with human height?

Yes. rs11012077 was identified in a genome-wide association study of 5.4 million individuals as one of 12,111 variants significantly associated with adult height. Together, these variants explain about 40% of height variation in people of European ancestry.

How much does rs11012077 affect height?

The study that identified rs11012077 does not report an individual effect size for this specific variant. It is one of 12,111 height-associated variants, and their combined contribution explains roughly 40% of height variation in European-ancestry populations and 10-20% in other populations.

Why is height prediction less accurate in non-European populations?

The 12,111 height-linked variants explain about 10-20% of height variation in non-European populations, compared to 40% in European populations. Researchers attribute this to differences in linkage disequilibrium (the correlation between nearby genetic variants) and allele frequencies across ancestries, rather than different underlying biology.